Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats

JS Master; MA Zimanyi; KV Yin; KM Moritz; LA Gallo; M Tran; ME Wlodek; MJ Black

Journal article

Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats

JS Master, MA Zimanyi, KV Yin, KM Moritz, LA Gallo, M Tran, ME Wlodek, MJ Black

Clinical and Experimental Pharmacology and Physiology | Published : 2014

DOI: 10.1111/1440-1681.12303

Abstract

Summary: Epidemiological studies have shown an association between low birthweight and adult disease development with transmission to subsequent generations. The aim of the present study was to examine the effect of intrauterine growth restriction in rats, induced by uteroplacental insufficiency, on cardiac structure, number, size, nuclearity, and adult blood pressure in first (F1) and second (F2) generation male offspring. Uteroplacental insufficiency or sham surgery was induced in F0 Wistar-Kyoto pregnant rats in late gestation giving rise to F1 restricted and control offspring, respectively. F1 control and restricted females were mated with normal males, resulting in F2 control and restri..

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University of Melbourne Researchers

Mary Wlodek Author

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Grants

Funding Acknowledgements

This study was supported by National Health and Medical Research Council of Australia (NH&MRC) project grant to MEW. Support was also received from March of Dimes and Heart Foundation grants to MEW and KMM. JSM was supported by the Fay Marles Scholarship (FMS) from The University of Melbourne and an MMI-CSIRO scholarship.